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这就表明,肿瘤要么可以促使生物被膜形成,要么就是生物被膜可以帮助引发机体肿瘤的产生,粘膜层被“攻破”将会帮助细菌直接同宿主结肠组织的上皮细胞进行接触反应,这或许是引发结肠癌的前提
在健康人机体中,结肠由粘膜层所包裹覆盖,免于细菌侵入其中,值得注意的是,在这项最新研究中,研究者却发现在携带肿瘤相关的生物被膜的结肠癌患者机体中的粘膜层的无肿瘤区域也充满了生物被膜
研究者jessica mark welch表示,这项研究中我们首次发现细菌生物被膜和结肠癌的发病直接相关,同时该研究也将帮助我们绘制出新型的微生物群落结构图;而在临床中利用组合成像技术就可以对升结肠组织的癌变前期及癌变期症状进行诊断
pmid:右半结肠癌早期症状
doi:10.1073/pnas.
2014年12月15日 讯 /生物谷bioon/ --2012年科学家们首次编制了人类机体中正常细菌的组成目录,当时科学家们就发现人类许多疾病的发生和微生物菌落的分布直接相关而近日发表在国际杂志pnas上的一篇研究论文中,来自美国海洋生物研究所的科学家就揭示,升结肠癌性组织或具有生物被膜的特性,而生物被膜恰恰是细菌产生的大量粘稠的细胞外基质
pmc:
christine m. dejeaa, elizabeth c. wickb, elizabeth m. hechenbleiknerb, james r. whitec,1, jessica l. mark welchd, blair j. ross结肠癌早期症状ettid, scott n. petersone,2, erik c. snesrude,3, gary g. borisyd, mark lazarevf, ellen steinf, jamuna vadivelug, april c. roslanih, ausuma a. malikh, jane w. wanyirif, khean l. gohi, iyadorai thevambigag, kai fuj, fengyi wanj,k, nicolas llosal, franck housseauk, katharine romansm,n, xinqun wuf, floren结肠癌术后饮食cia m. mcallisterk, shaoguang wuf, bert vogelsteinm,n, kenneth w. kinzlerm,n, drew m. pardollf,k, and cynthia l. searsa,f,k,4
microbiota organization is a distinct feature of proximal colorectal cancers
随后研究者又发现降结肠组织的肿瘤和生物被膜并无关联,文章中研究者引入了组合成像技术来进行该研究,研究人员利用不同颜色的荧光探测剂来标记生物被膜中的不同细菌,用来揭示这些微生物群落的3-d结构,结果表明和结肠癌二线化疗方案升结肠肿瘤相关的生物被膜中包含着许多种不同的细菌,这些细菌具有高度的多样性,而侵入粘膜层的部分生物被膜则包含有所有细菌的亚群,而并不单单是一种细菌(生物谷bioon.com)
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environmental factors clearly affect colorectal cancer (crc) incidence, but the mechanisms through which these factors function are unknown. one prime candidate is an altered colonic mi乙状结肠癌症状crobiota. here we show that the mucosal microbiota organization is a critical factor associated with a subset of crc. we identified invasive polymicrobial bacterial biofilms (bacterial aggregates), structures previously associated with nonmalignant intestinal pathology, nearly universally (89%) on right-si结肠癌分期及治疗ded tumors (13 of 15 crcs, 4 of 4 adenomas) but on only 12% of left-sided tumors (2 of 15 crcs, 0 of 2 adenomas). surprisingly, patients with biofilm-positive tumors, whether cancers or adenomas, all had biofilms on their tumor-free mucosa far distant from their tumors. bacterial biofilms were associated with diminis横结肠癌晚期症状hed colonic epithelial cell e-cadherin and enhanced epithelial cell il-6 and stat3 activation, as well as increased crypt epithelial cell proliferation in normal colon mucosa. high-throughput sequencing revealed no consistent bacterial genus associated with tumors, regardless of biofilm status. howeve结肠癌能活多久r, principal coordinates analysis revealed that biofilm communities on paired normal mucosa, distant from the tumor itself, cluster with tumor microbiomes as opposed to biofilm-negative normal mucosa bacterial communities also from the tumor host. colon mucosal biofilm detection may predict increase乙状结肠腺癌d risk for development of sporadic crc.
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